Metal-free thioesterification of α,β-unsaturated aldehydes with thiols
نویسندگان
چکیده
For the first time, synthesis of thioesters starting from enals and thiols has been performed in presence a bulky N-heterocyclic carbene (NHC) as catalyst.
منابع مشابه
Chiral squaramide-catalysed one-pot enantioselective sulfa-Michael addition/thioesterification of thiols with α,β-unsaturated N-acylated succinimides.
A novel highly enantioselective one-pot dithiolation through sulfa-Michael addition/thioesterification of thiols with α,β-unsaturated N-acylated succinimides catalysed by squaramide has been developed. This organocatalysed reaction proceeded well in high to excellent yields (up to >99%) to afford useful bioactive β-sulfated thioester derivatives with high enantioselectivities (up to 96% ee).
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ژورنال
عنوان ژورنال: Organic chemistry frontiers
سال: 2022
ISSN: ['2052-4110', '2052-4129']
DOI: https://doi.org/10.1039/d2qo00678b